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Over 4 million people worldwide have received a prosthetic heart valve, and an estimated 300,000 valves are being implanted every year. Prosthetic heart valves improve quality of life and survival of patients with severe valvular heart disease, but the need for antithrombotic therapy to prevent thrombotic complications in valve recipients poses challenges for clinicians and patients. Here, we review antithrombotic therapies for patients with prosthetic heart valves and management of thromboembolic complications. Advances in antithrombotic therapy and valve technologies are likely to improve the management of patients with prosthetic heart valves in developed countries, but the most important unmet need and potential for benefit from these new therapies is in developing countries where a massive and rapidly increasing burden of valvular heart disease exists. |
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anticoagulant,discontinuation
anticoagulant,treatment
cerebrovascular accident,prevention of
coumarin
dental procedure,neurologic complications with
efficacy
heart valve,prosthetic
heart valve,prosthetic,bioprosthetic
heart valve,prosthetic,mechanical
heart valve,prosthetic,thrombosis
INR values
prevention of neurologic disorders
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